Ms. Scarlet is the first to roll for the Clue board game. In Cluedo, she is the guest who first discovers Dr. Black's dead body.

In Clue: The Movie, Ms. Scarlet is being blackmailed for running a telephone escort service, where Yvette is employed. In the first ending, Ms. Scarlet is found responsible for all six murders. In the third ending, Ms. Scarlet killed the cop, because he told Mr. Boddy about her escort service.

In Clue: The Movie, Ms. Scarlet is played by Lesley Ann Warren.

Ms. Scarlet is an oriental spy in the VCR game. Her assignment is to discover the formula for Professor Plum's poison, which is in fact intended to be a floor wax. When he discovers her plan, however, Plum eats the paper on which the formula is written.

In the VCR Mystery Game, Ms. Scarlet is played by Janet Wong.

Ms. Scarlet is known as Ms. Vivienne Scarlett in the Puzzle Set.

Ms. Scarlet plays a young golddigger in the video game. Her theme music is sexy and mysterious.

In the Clue books, Ms. Scarlet is constantly preoccupied with cosmetics, mirrors, and vanity in general. She also constantly throws herself at men, flirts with men, eats off of mens' plates, and makes generally humourous remarks, all of which Mrs. Peacock declares rude.

In Clue Jr., Ms. Scarlet is transformed into a little girl named Samantha Scarlet. As with all of the other characters, Samantha Scarlet is unhealthily drawn to the Clue Jr. board game. Her mother, Mrs. Scarlet, occasionally drives the kids around.

Lisa Simpson plays Ms. Scarlet in the Simpsons Clue game itself, but on one of the versions of the game box, Lisa appears as Mrs. Peacock and Mrs. Krabappel as Ms. Scarlet.